•Use 25-50% lower dose for opioid-naive patients •Reduce 25-50% for incomplete cross-tolerance •Always use equianalgesic table for verification •Consult pain specialist for complex cases
📚 Evidence & GuidelinesClass I Recommendation
★★★★★(2001)
Citation: Mercadante S. Opioid rotation for cancer pain: rationale and clinical aspects. Cancer. 1999;86(9):1856-1866.
For reference only. Opioid conversion requires clinical expertise.
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