Age (years)

AST (SGOT, U/L)

ALT (SGPT, U/L)

Platelet Count (×10⁹L)

💡 Formula: FIB-4 = (Age × AST) / (Platelet × √ALT)

FIB-4 Index

📊 Interpretation

💡 Clinical Notes

•Low FIB-4 (<1.30): Strong NPV for advanced fibrosis
•High FIB-4 (>2.67): Strong PPV for advanced fibrosis
•Indeterminate (1.30-2.67): Consider additional testing
•Useful for NAFLD/NASH screening
•Non-invasive alternative to liver biopsy

📚 Evidence & Guidelines Class I Recommendation

★★★★★ (2006)

Citation: Sterling RK, Lissen E, Clumeck N, et al. Development of a simple noninvasive index to predict significant fibrosis in patients with HIV/HCV coinfection. Hepatology. 2006;43(6):1317-1325.

Guideline: AASLD NAFLD Guidelines

📖 View on PubMed

class="disc">⚠️ Medical Disclaimer

For medical reference only. Use with other clinical data.

🫁 FIB-4 Index

📊 Interpretation

💡 Clinical Notes